| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2024-03-31 |
| タイトル |
|
|
タイトル |
フロセミド錠の先発医薬品および後発医薬品の溶出性比較試験 |
|
言語 |
ja |
| タイトル |
|
|
タイトル |
Comparative dissolution study of original and generic furosemide tablets |
|
言語 |
en |
| 著者 |
鶴留, 優也
船木, 智陽
堀口, 道子
牛島, 健太郎
|
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Dissolution test |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Disintegration test |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
branded generic drug |
| 主題 |
|
|
言語 |
ja |
|
主題Scheme |
Other |
|
主題 |
溶出試験 |
| 主題 |
|
|
言語 |
ja |
|
主題Scheme |
Other |
|
主題 |
崩壊試験 |
| 主題 |
|
|
言語 |
ja |
|
主題Scheme |
Other |
|
主題 |
後発医薬品 |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Furosemide is one of the most used loop diuretics. While several generic versions of furosemide tablets are available in clinical situation, similarities in dissolution property of these tablets have not been reported. Hence, we compared the differences of dissolution property of furosemide 40 mg tablets between the original and generic A in dissolution and disintegration tests.\n Simple suspension of the generic A tablets showed a greater particle dispersion than that of the original product. The furosemide dissolution rate of generic A in the dissolution test showed a significant small compared to the original product during from 2 to 4 minutes after the beginning, but it became higher, in turn, at 30 minutes after. In the disintegration test, the generic A tablet had a longer disintegration time of 1-2 minutes than the original product. The generic A tablet contained specific additives of coating agents such as titanium dioxide, Hypromellose, and PEG6000. The presence of insoluble titanium dioxide causes white cloudiness in simple suspension of the generic A tablet. Both Hypromellose and PEG6000 were supposed to increases the dispersibility of furosemide, which could lead to the increased dissolution rate of the generic A tablet. These findings of this study on furosemide tablet are considered to provide helpful information for an alternative use with generic agents. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
山陽小野田市立山口東京理科大学 |
|
言語 |
ja |
| 出版者 |
|
|
出版者 |
Sanyo-Onoda City University |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| 資源タイプ |
|
|
資源タイプ識別子（シンプル） |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ（シンプル） |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
ja : 山陽小野田市立山口東京理科大学紀要
en : Bulletin of Sanyo-Onoda City University
号 7,
p. 39-43,
発行日 2024-03-31
|
SU10007000005.pdf (5.8 MB)
